核酸定制、核酸包封及方案技术支持服务

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核酸定制、核酸包封及方案技术支持服务

应用文献:

1. Human adipose-derived multipotent stromal cells enriched with IL-10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift. Bioeng Transl Med. 2024; e10711.


2. Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection. Signal Transduct Target Ther. 2024 Jun 21;9(1):150. 


3. ROS-Responsive Injectable Hydrogel Loaded with SLC7A11-modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats. Adv Healthc Mater. 2024 May 1:e2401103.


4. Sustained delivery of chemically modified mRNA encoding amelogenin from selfassembling hydrogels for periodontal regeneration.  Composites Part B: Engineering.Available online 21 December 2023, 111162.


5. Adipose-derived stem cells enriched with therapeutic mRNA TGF-β3 and IL-10 synergistically promote scar-less wound healing in preclinical models. Bioeng Transl Med. 2023 Nov 10;9(2):e10620. 


6. Vascular endothelial growth factor a modified mRNA engineered cellular electrospun membrane complexes promotes mouse skin wound repair. Materials Today Bio. 2023 Aug 23;22:100776.


7. Enhanced adipose-derived stem cells with IGF-1-modified mRNA promote wound healing following corneal injury. Mol Ther. 2023 Aug 2;31(8):2454-2471. 


8. Safe and Effective Delivery of mRNA Using Modified PEI-Based Lipopolymers. Pharmaceutics. 2023 Jan 26;15(2):410. 


9. Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis, Biomater Res . 2023 Jan 17;27(1):3. 


10. Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI, Molecular Therapy . 2023 Jan 4;31(1):211-229.


11. Combination of chemically modified SDF-1α mRNA and small skin improves wound healing in diabetic rats with full thickness skin defects. Cell Prolif. 2022 Dec;55(12):e13318. 


12. Engineered adipose-derived stem cells with IGF-1-modified mRNA ameliorates osteoarthritis development. Stem Cell Res Ther 2022 Jan 15;13(1):19. 


13. Chemically Modified SDF-1α mRNA Promotes Random Flap Survival by Activating the SDF-1α/CXCR4 Axis in Rats. Front. Cell Dev. Biol. 2021 Feb 4; 9:623959.


14. BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways. Commun Biol. 2021 Jan 19;4(1):82


15. Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model. Stem Cell Res Ther. 2020 Nov 19;11(1):490. 


16. Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia. J Control Release. 2019 Sep 28;310:103-114.


17. Lipid nanoparticle-assisted miR29a delivery based on core-shell nanofibers improves tendon healing by cross-regulation of the immune response and matrix remodeling. Biomaterials. Volume 291, 2022, 121888.


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                                                        案例1结果                                                                                案例2结果



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