LS-COMPACT is a high-performance, cost-effective light sheet microscope working on 3D imaging for various modelanimals and tissue with high speed, high resolution and multi-signals. it can be applied in wide range of fundamen.tal life science research, pharmaceutical industry and clinical diagnose, Based on the traditional light sheet micros.copy, LS-COMPACT is designed with the real-time imaging model and parameters adjustment functions and isupgradable to LS18.