PNI - Nanomedicine Assembling System
The NanoAssemblr™ Blaze™
The NanoAssemblr™ Blaze™

Seamless translation of nanomedicines from discovery to clinical development

Brand: Precision Nanosystems

Place of Origin: Canada

Model: Blaze



The NanoAssemblrTM BlazeTM

The NanoAssemblr Blaze is enabling for researchers and drug development programs that are interested in nanoparticle research and synthesis. The dynamic volume range allows researchers to use the Blaze for nanoparticle discovery, preclinical toxicology testing and for early Chemistry, Manufacturing and Controls (CMC) studies.

The NanoAssemblr Blaze was developed to bridge the gap between nanoparticle discovery and clinical development. The Blaze can manufacture between 10 mL and 1 L per batch. Nanoparticles made on Precision NanoSystems’ Benchtop instrument scale seamlessly to the Blaze with minimum process development accelerating transfer of nanoparticle candidates towards clinical development.


Particle Size Control: Combining reproducible microfluidics with precise fluid injection allows users to efficiently find and dial-in the optimal conditions for nanoparticle formation.

Efficient Drug Loading: Improved drug loading or encapsulation efficiency compared to conventional methods.

Scalable Production: The continuous flow microfluidic process can be scaled up by increasing total volume injected through a single mixer, or by employing multiple mixer in parallel without affecting the underlying conditions of nano particle synthesis. This allows formulations to be optimised at bench scales, and scaled up with little to no re-optimisation at each change in batch size.

Versatile: Suitable for creating a variety of different particles including:
l Biodegradable polymer nanoparticles (ex: PLGA)
l Amphiphilic block co-polymer micelles (ex: PEG-PLA)
l Dendrimer nanoparticles
l Polymer-drug conjugates
l Nucleic acid Lipid Nanoparticles (LNP)
l Lipsomes, Emulsions, Organic/ Inorganic Nanoparticles


l Gene delivery and screening via high cell transfection efficiency

l Nanoparticle design and screening

l Targeted delivery of small molecules

l Drug development

l Lipid nanoparticles formulation


       The NanoAssemblr Blaze Cartridge is used with the NanoAssemblr Blaze system for the manufacture of  nanoparticles across a range of volumes. These disposable cartridges are single use and allow for formulation of a variety of nanoparticles via nanoprecipitation.

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