Choose Etaluma’s State of the Art Microscopy Modules for Your Development Project

Date:2019/4/12 13:11:35

When designing products that include a microscopy or cell imaging function, often one must decide what to buy and what to design in-house. An OEM-components partnering strategy can significantly augment the expertise of your own team and eliminate the risks from not knowing what you don’t know. It can free up internal resources for other projects, reduce long-term costs, and ultimately help get your products to market faster.

Compact 3-color fluorescence Optics Module with USB3 camera

Solid-state optics in which the 3 channels turn on consecutively

Etaluma’s Proprietary Optics Engine (photo above)

An entire microscope in the palm of your hand! Or in your instrument’s hardware.  Important features:

  • Solid-state channel switching with no moving parts and no pixel shift

  • Uses multi-bandpass filter sets from Semrock or Chroma

  • Etaluma’s high resolution, near diffraction-limited optics

  • 4-inch light path with high photon capture

  • C-mount for use of newer generation USB3 cameras (see below)

  • Now configured with an LED controller for fine control of LED illumination (see below)

  • Compatible with RMS-threaded, infinity corrected, 45 mm parfocal distance objectives

Contact us to configure these near diffraction-limited optics to your own specifications.

Solid-state optics in which the 3 channels turn on consecutively

Choice of Fluorescence Wavelengths

Our standard Optics Module detects the following:

  • Blue (e.g., Dapi):  Excitation 370-410 nm; Emission 429-462 nm

  • Green (e.g., FITC):  Excitation 473-491 nm; Emission 502-561 nm

  • Red: (e.g., Texas Red):  Excitation 580-598 nm; Emission 612-680 nm

We have built other color combinations as well including those for Cy3 and Cy5.  Let us know what you need.

Automated XY stage and autofocus

Automated Motion Control at Your Precision

Our standard LS720 has walk-away automation in which the labware moves in both X and Y and the motorized focus provides autofocus and Z-stacks.

We are also developing XY Motion Control that moves the Optics Module under the labware, which provides the use of multiple and varied labware within the same imaging experiment.

Lab on a Tip Application

Complete overhead clearance allows plumbing, micromanipulators, compact incubator chambers, and perfusion experiments. Add reagents while recording live video.

Double Side-by-Side Optics Microscope

How about two live views in the same disposable? Sample and Control run simultaneously and side by side. What can you accomplish with such a system?

Two experiences illustrate the value of choosing Etaluma as your OEM partner:

The first is the case of an academic founder with a strong microscopy background.  The company wanted to release an integrated instrument for processing and imaging samples.  It needed liquid handling, incubation, firmware integration, scheduling software, and a GUI in addition to the microscopy component.  Being the most comfortable with the microscopy component, he began to design a microscope from scratch with components from a highly respected optical components vendor.  Unfortunately this approach did not converge on a commercially viable design.  The components were too expensive, even in quantity, because they were designed generically without known specifications.  In addition, while he focused on this seemingly simple part of the instrument, he did not pay enough attention to running the business.

The second case involves not knowing what you don’t know.  In this case, the customer was a large corporation that wanted to get into the bioanalysis field.  They have world class manufacturing of consumer products and wanted to apply this skill to bioanalytical instrumentation.  They are astute enough to realize they should buy the microscopy component from Etaluma.  When we learned that they would like to incorporate XYZ movement, we suggested our automated OEM offering.  But they deferred to their internal resources and continued development in-house.  Almost a year went by before they admitted they didn’t consider key specifications.  These included vibration isolation, perpendicularity of the optic axis, and motion control accuracy and precision requirements.  A few person years of effort went into learning what they didn’t know.

Dedicated features with just the right amount of flexibility

The optics of microscopy can have very complex functionality and performance requirements. In addition, the risk of over design and under design are significant.  One of the most important steps in defining an effective OEM strategy is to carefully draft specifications and customer use scenarios. What features or performance factors are a ‘must have’ and what can come later, i.e., are version 2?  Factors important to consider are customer expectations, size, serviceability, user interface, and pricing.

An old automation saying important to consider is, “the easiest step to automate is the one you eliminate”. By removing superfluous features, the product development process becomes streamlined. Good design philosophy is also reflected in the KISS principle, i.e., “keep it simple, stupid”.  Extra parts, components, and functionality cost time and money in inventory, material handling, development, product testing, and life-cycle management.  Etaluma also believes in eliminating moving parts wherever possible.  This is seen most dramatically in our multichannel, solid-state, Pinkel filter set configuration for pixel shift-free images and composite images.  No moving parts also increases the speed with which we can switch excitations.  We also often ask what hardware can be “done at the software stage”.

Under design is also risky — especially when it results from eliminating functionality mid-stream to mitigate project delays. Why waste time trying to design something that others have already perfected?

Microscopy is our business. 

As an OEM supplier, our in-house photonics experts, manufacturing processes, and off-the-shelf modular components can help ensure the best product as quickly as possible.

OEM microscopy outsourcing improves efficiency

At the beginning of a new product development phase, consider whether it might be more efficient to outsource specific components or even a fully integrated private label LS Microscope.  You can save significantly on development costs and speed up time to market by working with us as an OEM partner that offers:

  • Established performance specifications

  • Off-the-shelf CORE optics components or customized configurations

  • Pre-tested optics and motion modules

  • Expertise in microscopy and automation

  • Custom colors and cameras available

  • Software Development Kit and Micromanager Device Adapter available.

Combining this technology-focused bottom-up assessment with a top-down feature-focused approach enables you to best determine how to leverage your existing resources to the maximum extent, and take full advantage of the cost and time efficiencies that we as an OEM microscopy partnership can bring.

  • Why use Etaluma as your OEM partner for microscopy?

  • When you need your team needs to focus on their specialized expertise

  • When you need a component that is ready to integrate

  • When you need a component or customized configuration that is already designed, tested and documented

An effective OEM outsourcing strategy executed with the right microscopy OEM partner results in the best product and the most efficient use of resources. It ultimately results in one overarching benefit:  Getting to market faster.

About Nuohai Life Science

Nuohai Life Science co., Limited is committed to equipping scientists in life science field with advanced experimental and research & manufactural equipments, related consumables, reagents as well as offering professional application and technical support services. We aim to constantly promote the development of new technology in life science field with the timely introduction of the latest foreign technology and products. Meanwhile, Nuohai Life Science provide CRO and CMO service to acdamic and industrial customers, to satisfy every demand in the R&D and manufacturing. 

Nuohai Life Science not only brings new top products to our customers, but also pays attention to training professional sales, engineers and after-sales service team. With customer-oriented value in heart, Nuohai Life Science has earned the trust of our customers and enjoyed good reputation with comprehensive life science solution and sound after-sales service.

Nuohai Life Science was established in 2004 with headquarter in Shanghai and 8 offices in Beijing, Guangzhou, Chengdu and other first-tier cities, providing a nationwide selling & service networking. Customer service is just a call away.


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